Basal cell carcinoma - Basale Sel Carcinoma
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Ulcerated lesions dy't ynfloed op 'e hûd fan' e noas yn in âlder yndividu wurde faak diagnostisearre as Basale Sel Carcinoma (Basal cell carcinoma). De noas is in mienskiplik plak fan foarkommen foar dit soarte hûdkanker.
Basale Sel Carcinoma (Basal cell carcinoma) kin foarkomme mei ûnregelmjittige rânen en zweren.
Basale Sel Carcinoma (Basal cell carcinoma) kin wurde fersin mei wart.
References
Basal cell carcinoma (BCC) is it meast foarkommende type hûdkanker. Blootstelling oan sinneljocht is de wichtichste oarsaak. Hast alle BCC-gefallen litte oeraktive Hedgehog-sinjalearring sjen yn 'e molekulêre analyze. Ferskillende behannelingen binne beskikber en keazen op basis fan weromfallrisiko, belang fan weefselbehâld, pasjint foarkar, en omfang fan sykte.
Basal cell carcinoma (BCC) is the most common malignancy. Exposure to sunlight is the most important risk factor. Most, if not all, cases of BCC demonstrate overactive Hedgehog signaling. A variety of treatment modalities exist and are selected based on recurrence risk, importance of tissue preservation, patient preference, and extent of disease.
Basal cell carcinoma (BCC) is the most common malignancy. Exposure to sunlight is the most important risk factor. Most, if not all, cases of BCC demonstrate overactive Hedgehog signaling. A variety of treatment modalities exist and are selected based on recurrence risk, importance of tissue preservation, patient preference, and extent of disease.
Basal cell carcinomas binne it meast foarkommende type hûdkanker yn folwoeksenen mei ljochte hûd fan 50 jier en âlder. Harren oantal nimt wrâldwiid ta, benammen troch bleatstelling oan sinneljocht. Bepaalde genetyske omstannichheden kinne minsken gefoelich meitsje foar it ûntwikkeljen fan dizze kankers op in jongere leeftyd. Basal cell carcinomas fariearje yn earnst, fariearjend fan maklik te behanneljen oerflakkige as nodulêre lesions oant wiidweidigere dy't diskusje nedich binne yn spesjalisearre medyske teams. Prognoaze hinget ôf fan 'e kâns dat kanker weromkomt of har fermogen om tichtby weefsel te beskeadigjen. Surgery is de standert behanneling foar de measte gefallen, garandearret krekte ferwidering en lege kânsen op weromkomst. Minder invasive metoaden kinne oerflakkige lesions effektyf behannelje.
Basal cell carcinomas are the most frequent skin cancers in the fair-skinned adult population over 50 years of age. Their incidence is increasing throughout the world. Ultraviolet (UV) exposure is the major carcinogenic factor. Some genodermatosis can predispose to formation of basal cell carcinomas at an earlier age. Basal cell carcinomas are heterogeneous, from superficial or nodular lesions of good prognosis to very extensive difficult-to-treat lesions that must be discussed in multidisciplinary committees. The prognosis is linked to the risk of recurrence of basal cell carcinoma or its local destructive capacity. The standard treatment for most basal cell carcinomas is surgery, as it allows excision margin control and shows a low risk of recurrence. Superficial lesions can be treated by non-surgical methods with significant efficacy.
Basal cell carcinomas are the most frequent skin cancers in the fair-skinned adult population over 50 years of age. Their incidence is increasing throughout the world. Ultraviolet (UV) exposure is the major carcinogenic factor. Some genodermatosis can predispose to formation of basal cell carcinomas at an earlier age. Basal cell carcinomas are heterogeneous, from superficial or nodular lesions of good prognosis to very extensive difficult-to-treat lesions that must be discussed in multidisciplinary committees. The prognosis is linked to the risk of recurrence of basal cell carcinoma or its local destructive capacity. The standard treatment for most basal cell carcinomas is surgery, as it allows excision margin control and shows a low risk of recurrence. Superficial lesions can be treated by non-surgical methods with significant efficacy.
De primêre behanneling foar BCC is sjirurgy. Foar hege risiko of weromkommende BCC, benammen yn krityske gebieten, wurdt mikrografysk kontroleare sjirurgy oanrikkemandearre. Pasjinten mei leech-risiko oerflakkige BCC kinne topike behannelingen as destruktive metoaden beskôgje. Fotodynamyske terapy wurket goed foar oerflakkige en lege risiko nodulêre BCC's. Foar lokaal avansearre of metastatyske BCC wurde Hedgehog-ynhibitoren (vismodegib, sonidegib) oanrikkemandearre. As der sykteprogression of yntolerânsje is foar Hedgehog-ynhibitoren, kin immunotherapy mei anti-PD1 antibody (cemiplimab) wurde beskôge. Radiotherapy is in goede opsje foar pasjinten dy't gjin sjirurgy kinne hawwe, benammen âldere pasjinten. Elektrochemotherapy kin beskôge wurde as sjirurgy of radiotherapy gjin opsje is.
The primary treatment for BCC is surgery. For high-risk or recurring BCC, especially in critical areas, micrographically controlled surgery is recommended. Patients with low-risk superficial BCC might consider topical treatments or destructive methods. Photodynamic therapy works well for superficial and low-risk nodular BCCs. For locally advanced or metastatic BCC, Hedgehog inhibitors (vismodegib, sonidegib) are recommended. If there's disease progression or intolerance to Hedgehog inhibitors, immunotherapy with anti-PD1 antibody (cemiplimab) can be considered. Radiotherapy is a good option for patients who can't have surgery, especially older patients. Electrochemotherapy could be considered if surgery or radiotherapy isn't an option.
The primary treatment for BCC is surgery. For high-risk or recurring BCC, especially in critical areas, micrographically controlled surgery is recommended. Patients with low-risk superficial BCC might consider topical treatments or destructive methods. Photodynamic therapy works well for superficial and low-risk nodular BCCs. For locally advanced or metastatic BCC, Hedgehog inhibitors (vismodegib, sonidegib) are recommended. If there's disease progression or intolerance to Hedgehog inhibitors, immunotherapy with anti-PD1 antibody (cemiplimab) can be considered. Radiotherapy is a good option for patients who can't have surgery, especially older patients. Electrochemotherapy could be considered if surgery or radiotherapy isn't an option.
Risikofaktoaren omfetsje bleatstelling oan ultraviolet ljocht, bestralingstherapy, langduorjende bleatstelling oan arsenikum en minne ymmúnsysteemfunksje (bgl. orgaantransplantaasje). Bleatstelling oan UV-ljocht yn 'e jeugd is benammen skealik.
Nei diagnoaze troch biopsie is behanneling typysk troch sjirurgyske ferwidering. Dit kin wêze troch ienfâldige excision as de kanker is lyts; As de kanker net lyts is, wurdt Mohs sjirurgy algemien oanrikkemandearre.
Basale cell carcinoma makket teminsten 32% fan alle kankers wrâldwiid foar. Fan oare hûdkankers as melanoma binne sa'n 80% basale selkankers. Yn 'e Feriene Steaten wurde sa'n 35% fan 'e blanke mantsjes en 25% fan 'e blanke wyfkes op in stuit yn har libben beynfloede troch basale selkarsinoom.
○ Diagnose en behanneling
#Dermoscopy
#Skin biopsy
#Mohs surgery